Pharma

Home Industries Pharma

Process Optimization of solid dosage manufacturing

Process optimization encompasses widely varying activities whose objective is to reduce costs by eliminating unnecessary experimental steps, improving yields, shortening cycle times. Companies with manufacturing capacity should evaluate opportunities to lean their experimentation for better results from available assets.

Root Cause Analysis for Flow Related Issues

Detailed root cause for all failures will help to produce better product by making necessary corrections to factors identified such as:

  • Is blend uniform?
  • Are containers appropriate for better mixing developments?
  • Why powder doesn’t discharge uniformly?
  • When does blend reach requisite uniformity?
  • What are Risks and impacts due to existing hopper, feeder flows etc.,?
  • What is the current and needed tableting speed for required yield?

Troubleshooting Segregation Issues

Troubleshoot and address the related and relevant issues in the process of solid mixing to eliminate the revenue drains which often happens where bulk drugs happens to be costly to deal with

Hopper Geometry analysis & suggestion to avoid poor flow / bridging / arching

Typical industrial experiments has processing vessels with varied geometries. These vessel geometries play a key role during the mixing, drying, bagging etc., which ideally should contribute to powder flow, perhaps stays as a challenge for discharging of powders reliably. Therefore it becomes more important to understand the vessel measurements for a flow to happen meeting all required criteria in a processing line

Process scale-up consulting through simulations

Mixing