Drug Discovery

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Molecular Synthesis

PharmaDEM modelling capabilities will be helpful in Reaction feasibility analysis, Solvent impact, Estimation of drug substance stability, reaction safety assessment.

Computer aided drug design, Medicinal chemistry, Custom synthesis, Impurity synthesis, Gram to KG quantities, custom product can be synthesized using methods designed by PharmaDEM custom synthesis team or methods designed by Client’s chemist.

Custom synthesis products are backed by analytical data.

Advantages

  • Full integration of Insilico modelling capabilities in synthesis and scale up will reduce cost, time, waste and efforts.
  • Deep mechanistic understanding on process will be useful during commercialization.
  • Supplies can be made for the needs of pre-clinical and phase 1 trials.

Solubility Modelling

Solubility is an important property of unit operations in development of synthetic pharmaceutical processes

  • Use model as screening tool to guide initial experiments (rather than experimental screening).
  • High performance computing to screen large solvent space (pure, binary) : Synergy Effect; Anti Solvent Effectiveness; Temperature Dependence.
  • Guide experiments and additional (higher accuracy) models to explore promising spaces.
  • Clear understanding of model accuracy and its consequences.