PharmaDEM's cutting-edge Drug Development Software is at your fingertips. Our innovative platform offers a range of powerful tools designed to streamline every stage of drug development, from formulation modeling to absorption simulation.
PharmaDEM developed an innovative expert system (FormDEM) for drug-excipient compatibility evaluation, which is developed by integrating the empirical knowledge and chemistry rules-based interaction risk evaluation, Estimating thermodynamic properties, QM/MM modelling principles.
FormDEM is proprietary platform built by representing and utilizing the molecules characteristics which are coupled to a machine learning model to estimate the intersection between compatibility an incomparability. FormDEM can accurately represent the formulation excipients at exact weigh fractions which enables the calculations as much as close to the real formulation conditions, this means no more 50:50 binary drug-excipient compatibility studies. PharmaDEM By using PharmDE, the interaction risk between drugs and excipients could be quickly evaluated just by clicking mouse.
Often formulation are made with the knowledge and experience a formulation specialist has. This consumes lot of time as multiple studies and experiments to be made on the molecule and its properties and assessment on compatibilities. Formulation outcome will be grey until the results are seen at formulation stage and stability stage.
Formulation modelling by PharmaDEM a model informed Drug Development helps the R&D team to well assess in advance before any experiment is conducted on the compatibilities and experiment’s outcome through In Silico Drug Excipient compatibility studies& In Silico Stability shelf life. The detailed study on Structure, Properties, Performance and Processing will depict the actual characterization of a molecule helps optimize the solution at a molecular level to have a full control on Formulation Chemistry.
Benefits
Models can be built & refined with available clinical data; its decision-making powers expand with an eye toward the future drug label. In this stage, PharmaDEM can provide guidance regarding
In recent years, combining computational modelling and in vitro testing has become a feasible method for explaining biological complexity. As computing power advances, scientists will be able to investigate incredibly challenging models in greater depth and explain highly complicated real-world data.
Skin and membrane permeation experiments comprise an important step in the development of a transdermal, topical or ophthalmic formulations or toxicological risk assessment. These models can be helpful for choosing formulation and skin permeation enhancers which supports effective permeation of API into the skin membranes.
Utilization of systematically developed skin membrane models to gain a detail insights into the role of formulation and permeation enhancers will give an digital edge to optimize the formulation towards the desired bioavailability of API.
Model validated on in vitro human and pig skin and model membranes and in vivo rat skin.
Modelling Driven Formulation Design (MDFM) For Topical and formulation development:
