Our Competency & Capabilities

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Simulation Based Process Optimization and Trouble Shooting

  • Computational Modelling on Material compatibility, Solvent Screening, Reaction Feasibility, Crystallization, Impurities Assessment & Rejection, Toxicology studies, Stability Studies.
  • Packaging material selections for a given formulation.
  • Absorption Modelling, Solubility Modelling, Skin Permeability Modelling.
  • IVIVC (in vitro in vivo correlation) predictive modelling.
  • Identification of Critical Process Parameters (CPP) , Critical Material Attributes (CMA), Critical Quality Attributes (CQA) for manufacturing needs.
  • Powder discharge status and result assessment of the powder particles in chosen blending and mixer.
  • Blender/Mixer size, type and geometry assessment for an agreed yield.
  • Assessment of flow during tableting and appropriate tableting speed setting, and to address homogeneity & consistency issues during tableting.
  • Analytics & Statistics of powder flow during the experimental process.

Simulation Based Process Development

  • Desgin and Model Excipient Selection, Solubility and Formulation for OSD, Liquids, Topical.
  • Design and Model DEM (Discrete Element Method) simulation to accurately analyze the behavior of bulk solids involved in manufacturing process.
  • Design and Model CFD (Computational Fluid Dynamics ) simulations to accurately identify Crystallization stage and Isolation process operating conditions.
  • Detailed study and re-design process to meet the mixing efficiency and efficacy.
  • Computation and Calculations on forces acting on individual particles in mixing and blending.
  • Qualitative Analysis (segregation of particles), Quantitative Analysis (flow rate of particles).

Simulation Modelling Approaches

  • Computational Chemistry.
  • DEM (Discrete Element Method).
  • Coupling with computation fluid dynamics for two phase flow (gas/liquids).
  • Combining DEM with Population Balance Model (PBM).